Infrared, Near Infrared and Raman Spectroscopy

Advanced Research and QA/QC Solutions based on Infrared, Near Infrared and Raman Spectroscopy. Offering Infrared, Near Infrared and Raman spectrometer which fits a wide range of applications:

Bruker can now offer compliance to the ACLOA principle and offer the next generation Opus 8 Software that is compliant to both the FDA Data Integrity and cGAMP requirements.

For the white paper document for Data Integrity in a Pharmaceutical environment click here

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FTIR spectrometer

FT-NIR spectroscopy is today well established for quality control applications in all industries, including the pharmaceutical, food, agricultural and chemical sector.

It offers a practical alternative to the time-consuming, wet chemical methods and chromatographic techniques. FT-NIR is non-destructive, requiring no sample preparation or hazardous chemicals, making it quick and reliable for quantitative and qualitative analysis.

FT-NIR is ideal for rapid raw material identification and is also a powerful analysis tool capable of accurate multi-component quantitative analysis.

Its online capabilities based on fibre optic probe technologies allow a deep look into the process.

Bruker’s FT-NIR product line includes TANGO, MPA and MATRIX-I spectrometers for lab and at-line applications as well as the MATRIX-F series for process control and the TANDEM spectrometer for online tablet testing.

High End FTIR

FTIR Research Spectrometers

Bruker Optics offers a wide variety of laboratory FTIR spectrometers for all your Research applications.

  • The VERTEX Series is built on a fully upgradeable optics platform that is designed with the utmost flexibility in mind.
  • Offering the world’s commercially available highest resolution FTIR spectra, the IFS 125HR FTIR spectrometer is the ultimate research tool for FTIR spectroscopists.
  • CryoSAS semiconductor material quality control for photovoltaic and electronics industry.
  • The CONFOCHECK is a dedicated FTIR system for the investigation of proteins in water. It is very suitable to study protein stability and conformation.
  • The specifically developed PMA 50 module providing maximum flexibility and sensitivity is optimal for Polarization Modulated IR spectroscopic Applications.
  • TGA-FTIR combines the widely-used, quantitative analytical method thermogravimetric analysis with the qualitative FTIR spectroscopy.

FTIR / FT-NIR Process Spectrometers

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Optical spectroscopy is today a very important method for online process monitoring and optimization. Fiber-coupled probes allow a direct look into the process without delay.

The IR solution demonstrates its strengths especially for process development and optimization by simple peak analysis and trend monitoring. The main applications are today in the laboratory an pilot plants. The MATRIX-MF can be equipped with various detectors and probes and adapted to the specific requirements of a process application.

The strengths of the NIR solution are mainly in routine process applications. Due to the short measuring time, important process parameters for the monitoring and control are available almost immediately. A wide variety of probes or flow cells allow the use of NIR technology in almost all process conditions. The MATRIX-F with its internal 6 multiplexer offers an easy way to connect fiber-coupled measuring accessories using standard SMA connectors.

IRcube FTIR Spectrometer for OEM. Bruker’s high performance interferometer for Mid-Infrared Spectroscopy is now available for custom integrations.

The TANDEM is an online analysis system developed for the pharmaceutical tablet production to measure specifically as the active ingredient and humidity levels in addition to the physical parameters such as weight, thickness, diameter and hardness.

Numerous installations in the chemical, petrochemical and polymer industry as well as in the field of food and feed and the pharmaceutical production processes prove our experience.

All Bruker process spectrometers are characterized by robustness, long-term stability, and ease of maintenance.

Near Infrared Spectrometers

Competitive Edge with FT-NIR Spectroscopy

FT-NIR spectroscopy is today well established for quality control applications in all industries, including the pharmaceutical, food, agricultural and chemical sector.

It offers a practical alternative to the time-consuming, wet chemical methods and chromatographic techniques. FT-NIR is non-destructive, requiring no sample preparation or hazardous chemicals, making it quick and reliable for quantitative and qualitative analysis.

FT-NIR is ideal for rapid raw material identification and is also a powerful analysis tool capable of accurate
multi-component quantitative analysis.

Its online capabilities based on fibre optic probe technologies allow a deep look into the process.

Bruker’s FT-NIR product line includes TANGO, MPA and MATRIX-I spectrometers for lab and at-line applications as well as the MATRIX-F series for process control and the TANDEM spectrometer for online tablet testing.

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FTIR Microscopy and Raman Microscopy

FTIR Microscopes / Raman Microscopes

Bruker Optics offers a broad product line in FTIR and Raman Microscopy.

LUMOS is a fully automated stand-alone FTIR microscope. It combines best performance for visual inspection and infrared spectral analysis of micro samples with highest comfort in use.

The FTIR microscope HYPERION provides highest measuring sensitivity and spatial resolution for demanding research.

The SENTERRA II defines a new level of spectroscopic performance and user friendliness in the class of compact Raman microscopes.

Spectral Imaging

HYPERION Series FT-IR MicroscopesFTIR Microscopes / Raman Microscopes

The HYPERION is the culmination of more than 30 years of experience in FT-IR microscopy. Its high-quality design, including all optical, mechanical, and electronic components, provides high stability and reliability. Featuring many contrast enhancement tools, a wide variety of dedicated objectives, and chemical imaging, the HYPERION enables you to conduct the most sensitive microanalysis easily and efficiently. With its modular design, the HYPERION can be customized to the specific requirements of each application. Its field of use is extremely broad and includes materials research, polymers, chemicals, forensics, art conservation, and life sciences.

Sensitivity, Lateral resolution

The lateral resolution power of the HYPERION is only limited by diffraction of the incident light. Due to the high light-throughput a very high sensitivity is reached even at the highest lateral resolution.

The infrared beam path in the HYPERION is confocal. Apertures can be placed in conjugate image planes individually before and after the sample in transmission as well as in reflection. In the standard configuration, the HYPERION is equipped with a single transparent knife-edge aperture. Metal knife-edge apertures, iris apertures and aperture wheels are available as well as automatic, software-controlled knife-edge apertures.

Sampling flexibility

For FT-IR microscopic analysis in transmission, most samples must be optically thin and are typically cut in sections about 5–15 μm thick. If samples are deposited on reflective substrates, they are measured in reflection. As standard a 15x objective is used or as alternative for smaller samples more focussing objectives (20x, 36x) can be employed. However, because many samples are not transparent or reflective, they can be readily analyzed utilizing the attenuated total reflection (ATR) mode.
The dedicated ATR objective (20x) for the HYPERION combines a visual sample inspection without restrictions with highest sensitivity of the IR measurement. To be useful for samples ranging from soft to very hard, different pressures can be selected at the ATR objective. The internal pressure sensor reproducibly ensures optimal contact between the sample and the crystal even during automated ATR mapping measurements.
The measurement of very thin coatings on metallic surfaces often requires the grazing angle incidence reflection technique that enhances the interaction of the infrared light with the sample. Due to its patented design Bruker’s grazing angle objective (GAO) achieves a very high sensitivity that even allows analyzing mono-molecular layer. Furthermore measurements with polarized light are possible.

Spectral Range

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The spectral range of the HYPERION can be extended from the middle infrared to the near infared (NIR), even to the visible (VIS, up to 25,000cm-1) and down to the far infrared (FIR, down to 80 cm-1). To cover this extremely broad spectral range, many different detectors are available and can easily be exchanged by the user. The HYPERION can be equipped with up to two detectors in parallel, where the switching between positions is controlled by the software.

Software

The HYPERION is controlled by the OPUS software: an easy-to-use, powerful, all-in-one spectroscopy software. It includes the most comprehensive collection of data acquisition, processing, and evaluation functions. The software user interface can be customized for routine laboratory analysis as well as advanced R&D applications.
All resultant spectra, visual images, IR images, RGB and PCA plots, and annotations are stored within one file to ensure data integrity and make data manipulation straightforward.

Data acquisition using the HYPERION is very easy to accomplish, as it is guided by attractive wizards (OPUS 7.0). Many univariate and multivariate algorithms are implemented in OPUS to extract the relevant information out of the measured single or 3D data. Resulting IR images can be displayed in different 2D and 3D perspectives on top or beside the visible image.

Spectrometer Diagnostic

The HYPERION FT-IR microscope produces reliable data. The PerformanceGuard™ of the spectrometer includes permanent online diagnostics, realtime-display of the instrument status, and integrated automatic instrument tests (OQ, PQ). The OPUS software provides all options to perform the FT-IR analysis following the GMP and 21CFR-Part11 guidelines.

Flexible design

The HYPERION Series is a fully upgradeable microscope platform for conducting state-of-the-art optical and infrared analysis. The HYPERION 2000 includes all features found on the 1000 as does the 3000 with respect to the 2000.

  • HYPERION 1000: High performance infrared microscope with transmission and reflection capabilities, transparent knife-edge aperture and manual xy-stage. It is equipped with a nose piece with 15x cassegrain and 4x vis objective as well as binocular and video viewing.
  • HYPERION 2000: Fully automated microscope with motorized stage and an additional LCD screen on the microscope frame. All features of the HYPERION 1000 included.
  • HYPERION 3000: Fully automated FT-IR imaging microscope with modern focal plane array detector technology. The system includes also all features of the
  • HYPERION 2000.