Combat BRS System

The Combat BRS System is an innovative and patented recirculation system for the delivery of Hyperthermic Intra-VEsical Chemotherapy (HIVEC™). Hyperthermia has been shown to significantly increase the effectiveness of Mitomycin-C (MMC) in Non Muscle Invasive Bladder Cancer (NMIBC)1-2.

The Combat BRS System has been in clinical use since 2011, it is safe for patients and healthcare professionals, has similar patient tolerability to MMC at room temperature and is easy to use and adopt3.

The Combat BRS System uses an external dry conductive recirculation system. Our innovative and patented aluminium heat exchanger ensures efficient heat transfer and accurate temperature control within ± 0.5°C of the set temperature, whilst providing homogeneous drug and heat distribution throughout the bladder. Patient safety and comfort are paramount and the Combat BRS system has a range of safety features including; over temperature and high pressure audio and visual alarms as well as system auto cut off. At the end of a treatment the Combat BRS system also enables the removal of MMC from the patient for safe disposal.

The Combat BRS System harnesses accurate and effective heat control and the proven synergistic effects of chemo-hyperthermia to target NMIBC. The mutually enhancing effects of chemotherapy drugs and hyperthermia are well documented for their cytotoxic effects and are widely used in treating several types of cancer including bladder cancer4. Cancer cells become more permeable and are increasingly affected on many levels because of their inability to dissipate heat while the heat enhances the body’s natural immune responses5-7.

The Combat BRS System is portable, robust and easy to use. Simple to integrate into current treatment practice it requires minimal set up, no continuous monitoring and therefore minimal additional resources either physically, logistically or financially. Both the BRS system and disposable sets are affordable and through improving patient outcomes, the overall treatment cost can be reduced.


Bladder Recirculation System


Clinical Evidence


Medical Overview

A Patient’s Guide

to HIVEV Treatment

For more information on the COMBAT BRS send us an email