Digital and Physical New Student Starter Packs from CST are available from September 8, 2025 to November 28, 2025. 

Cell Signaling Technology are continuously looking for new ways to make a positive impact on the world. They are committed to doing the right thing for their customers, communities, and the planet. As part of their commitment, we are delighted to partner with them to offer you the choice to receive your NSSP in the format that suits you best: digitally or as a physical pack delivered to your lab.

There are a limited number of physical packs. Distribution will be on a first come, first served basis. So don’t wait, place an order today!

Please note this offer does not apply to contacts who are already registered with CST on or before December 1, 2024. Please see the terms and conditions below for full eligibility requirements.

General Terms and conditions: Eligibility for the Cell Signaling Technology^® New Student Starter Pack requires applicants to be legal residents of Andorra, Austria, Belgium, Bosnia and Herzegovina, Bulgaria, Czech Republic, Denmark, Egypt, Estonia, Finland, France, Germany, Greece, Hungary, Iceland, Ireland, Israel, Italy, Kazakhstan, Latvia, Lithuania, Luxembourg, Macedonia, Netherlands, Norway, Poland, Portugal, Romania, Serbia, Slovakia Republic, Slovenia, South Africa, Spain, Sweden, Switzerland, Turkey and United Kingdom and to provide a valid business, academic, professional organization shipping and email address. No private shipping addresses qualify for the offer. Professional email addresses must be new to Cell Signaling Technology (email addresses which have been entered on or before December 1, 2024 will not qualify for the offer). The content of the Student Starter Pack is subject to availability. Cell Signaling Technology reserves the right to substitute any item or to stop the promotion at any given time without notice. No product purchase is required to redeem this offer. Offer available while stocks last or until November 28, 2025. All personal information will be handled in accordance with the Cell Signaling Technology privacy policy, www.cellsignal.com/privacy

Our Channel Partner New England Biolabs has a special offer on NEBuilder Hifi Assembly Kits: 25% Off from October 1st to November 30th! 

NEBuilder HiFi DNA Assembly Kit is the #1 cited product for DNA assembly. 

• Assembly and transformation in two hours 
• Less screening/re-sequencing of constructs, with virtually error-free, high-fidelity assembly 
• Flexible sequence design (scar-less cloning) 
• Supplied with NEB 5-alpha chemically competent E. coli 

Packs include:  

• Luna® Universal qPCR Master Mix 
• Q5® High-Fidelity DNA Polymerase 
• Coaster 
• Lab Timer 
• Technical Guides 
• Year Planner 
• Sharpie® Marker 
• Luna qPCR Plate Planner 

Offer available from October 1 2025 to December 5 2025, or while supplies last.

Starter Packs are available to all new research students who are not currently on our mailing list and have not previously received a pack.

Please provide supervisor’s name and the name and departmental address of the student when you place your request.

Offer available while stocks last and no later than 05/12/2025 Contents may vary from those shown. Available in the UK and Republic of Ireland only.

To wrap up 2025, our channel partner Promocell is bringing back their popular promotion: Buy 1 Human Primary Cell, Get the Related Medium FREE!

From now until December 16, 2025 use promo code AN55854 in your order to get the discount.

This offer can be redeemed on a number of cell types including: Cardiac Myocytes Chondrocytes Dendritic Cells Endothelial Cells Epithelial Cells Fibroblasts Follicle Dermal Papilla Cells Keratinocytes Macrophages.

Offer excludes MSCs, blood cells, or their related media.

IHC-P: IHC analysis of paraffin-embedded human Pick’s disease brain (left) and Alzheimer’s brain (right) using #87145 (top) or TMEM106B (E7H7Z) Rabbit mAb #93334 (bottom)

TMEM106B Forms Amyloid Fibrils

TMEM106B, a type II transmembrane protein, is a lysosomal/late endosomal
protein and a genetic modifier of several neurodegenerative diseases and
general aging. A fragment consisting of residues 120-254 of TMEM106B forms
filaments in the brain in an age-dependent manner, suggesting its involvement
in the pathogenesis and progression of several neurodegenerative diseases.
#87145 is suitable for WB and IHC-P using human samples.

ChIP-Seq: Chromatin immunoprecipitations were performed with cross-linked chromatin from A549 cells cultured in phenol red-free MEM/charcoal-stripped FBS for 3 d, then treated with Dexamethasone #14776 (100 nM, 1 hr) and #32183, using SimpleChIP® Plus Enzymatic Chromatin IP Kit (Magnetic Beads) #9005. DNA Library was prepared using DNA Library Prep Kit for Illumina Systems (ChIP-seq, CUT&RUN) #56795. The figures show binding across chromosome 16 (upper), including MT2A (lower), a known target gene of PhosphoGlucocorticoid Receptor.

Master Regulator of Cellular Homeostasis

Glucocorticoid hormones regulate cell proliferation, inflammation, and metabolism through binding to the glucocorticoid receptor (GR)/NR3C1, a member of the
nuclear hormone receptor superfamily of transcription factors. Upon hormone
binding, GR is released from the chaperone complex and translocates to the
nucleus as a dimer. There, it associates with specific DNA sequences called
glucocorticoid response elements (GREs), thereby promoting or suppressing the
transcription of specific target genes. Phosphorylation of Ser211 in particular has
been reported to enhance transcriptional activation, promote nuclear translocation
and retention, and enhance interaction with cofactors. #32183 is suitable for WB,
IP, IF-IC, FC-FP, ChIP, and ChIP-seq using human, mouse, and rat samples