* Please note, this offer is only valid in the Republic of Ireland. For all other orders, please contact a Product Specialist.

Remove genomic DNA contamination with specialized columns, Proteinase K, RNase-free DNase and RNA stabilization reagent included.

The protocols are optimized to be quick and user‑friendly, ensuring total RNA pool is captured including small RNAs <200 nt RNA.

A transmembrane tyrosine kinase receptor essential for regulating biological phenomena. 

The FGF receptor family has four members (FGFR1, 2, 3, and 4) with 56-71% sequence identity. FGFR2 includes FGFR2IIIc (isoform 1, also known as BEK) and FGFR2IIIb (isoform 3, also known as FGFR2b). There are two major isoforms, FGFR2IIIb and FGFR2IIIb, which are produced by splicing of the third immunoglobulin-like domain, which is essential for ligand binding. FGFR2IIIb is mainly detected in epithelial cells and is overexpressed in estrogen receptor-positive breast and gastric cancers. FGFR2IIIb preferentially binds to its ligands FGF7, FGF10, and FGF22, and subsequently activates downstream signaling pathways, including PI3K/Akt and RAS-MAPK. Overexpression of FGFR2IIIb promotes aberrant signaling, leading to tumor cell proliferation. #52742 is suitable for WB and IHC-P with human samples. 

An important signaling molecule involved in cancer and rare diseases. 

SHP-2 is a protein tyrosine phosphatase (PTP) encoded by the PTPN11 gene. It is involved in RAS-MAPK, PI3K/Akt, and Jak/Stat signaling pathways that control cell proliferation, differentiation, and survival, and also plays a role in embryonic development, immune response, cell motility, and adhesion. SHP-2 dysfunction has been reported to be upregulated or activated in solid tumors, and development of SHP-2 inhibitors is underway. Mutations in the PTPN11 gene have also been reported to be associated with Noonan syndrome and juvenile myelomonocytic leukemia (JMML). #67019 is suitable for WB, IP, and IHC-P using human, mouse, and rat samples.