Check out our latest Research & Biotech promotions and events

Read Our Latest Newsletter

Order your FREE New Student Digital Starter Pack

Start your research journey with support from Cell Signaling Technology. Access a free digital resource pack featuring practical tools and guidance to help you shape your experimental design and approach lab work with confidence. Order yours between September 8 to December 31, 2026. (Terms & Conditions apply.)

You’ll also receive an invitation to our Applications 101 Webinar Series, designed to help you build essential lab skills and lay a strong foundation for a successful research career. The pack includes:

  • Application Guides
  • Invitation to Applications 101: Mastering Research Techniques
  • Tech Tip Videos
  • 25% Off Discount Voucher on Your First Order (expiration March 31, 2027)

Order Here

General Terms and Conditions: Eligibility for the Cell Signaling Technology® New Student Starter Pack requires applicants to be legal residents of Austria, Belgium, Bulgaria, Czechia, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Iceland, Ireland, Israel, Italy, Kazakhstan, Latvia, Lithuania, Luxembourg, Netherlands, Norway, Poland, Portugal, Qatar, Romania, Serbia, Slovakia, Slovenia, South Africa, Spain, Sweden, Switzerland, United Arab Emirates, and United Kingdom  and to provide a business, academic, professional organization email address. Professional email addresses must be new to Cell Signaling Technology (email addresses which have been entered on or before December 1, 2025 will not qualify for the offer). Cell Signaling Technology reserves the right to substitute any item or to stop the promotion at any given time without notice. No product purchase is required to redeem this offer. Offer available until December 31, 2026. All personal information will be handled in accordance with the Cell Signaling Technology privacy policy, www.cellsignal.com/privacy.

Don’t let your antibody become the variable

Recent industry discussions have reinforced the importance of antibody validation and data transparency. Not only does our channel partner Cell Signaling Technology (CST) carry 100 of the most cited antibodies according to CiteAb’s annual reports, their rigorous validation has been the cornerstone of their approach for more than 25 years. 

CST’s unique set of strategies for antibody validation are often used in combination, to give your lab a comprehensive data package that supports antibody performance. 

See the science behind CST validation

New Products This Month

InTraSeq® F’ Conjugate Antibody
Cocktail 1 #96928

InTraSeq: A549 cells, serum-starved (ss) 293 cells (ss 293), ss 293 cells treated with Human Insulin-like Growth Factor I (hIGF-I) #8917 (100 nM, 15 min) (ss 293 + hIGF-I), ss HeLa cells, ss HeLa cells treated with Human Interferon-gamma (hIFN-γ) Recombinant Protein #80385 (100 ng/mL, 30 min) (ss HeLa + hIFN-γ), HeLa cells treated with Staurosporine #9953 (1 μM, 3 hr) (HeLa + Staurosporine), HeLa cells treated with TPA (12-O-Tetradecanoylphorbol-13-Acetate) #4174 (200 nM, 30 min) and Ionomycin, Calcium Salt #9995 (1 μM, 30 min) (HeLa + TPA + Ionomycin), Jurkat cells, Jurkat cells treated with Rapid-Act T Cell Activation Kit (Human, Anti-CD3/CD28) #88179 (15 min) (Jurkat + Anti-CD3/CD28), K-562 cells, Ramos cells, THP-1 cells, and THP-1 cells treated with TPA (12-O-Tetradecanoylphorbol-13-Acetate) #4174 (80 nM, 24 hr) and Lipopolysaccharides (LPS) #14011 (1 μg/mL, 1 hr) (THP-1 + TPA + LPS) were analyzed using the Seurat computational package following single cell analysis. The right FeaturePlot displays the Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (197G2) Rabbit Monoclonal Antibody (InTraSeq F’ Conjugate 5023) #36075 expression.

Single-Cell Signaling Pathway Analysis

The InTraSeq F’ Conjugate Antibody Cocktail 1 enables the simultaneous measurement of RNA and proteins (cytoplasmic, cell surface, and nuclear), including post-translational modifications (PTMs), in single-cell assays. By overcoming the challenge where RNA levels do not necessarily reflect protein abundance or activity such as PTMs, it allows researchers to analyze diverse signaling pathways and elucidate molecular mechanisms using single-cell transcriptomics—insights that cannot be captured by single- cell RNA sequencing alone. #96928 is suitable for analysis using human and mouse samples.

NPM1 (C Mutant Specific) (E4A9G)
Rabbit Monoclonal Antibody #24786

 

IHC-P: IHC analysis of paraffin-embedded human acute myeloid leukemia using #24786.

Aberrant Cytoplasmic Localization in AML

C-terminal mutations in the NPM1 gene, observed in approximately 30% of acute myeloid leukemia (AML) cases, are known to cause the aberrant cytoplasmic localization of the NPM1 protein (NPM1c)—which normally resides in the nucleolus—via the inactivation of its nuclear localization signal and the acquisition of a nuclear export signal. Frequently associated with other co-occurring mutations (e.g., FLT3, DNMT3A, TET2, and SF3B1), NPM1 mutations serve as crucial targets for AML diagnosis, prognosis, therapy, and post-treatment monitoring. #24786 is suitable for IHC-P, FC-FP, and ChIP using human and mouse samples. It has been confirmed to specifically detect endogenous NPM1c without cross-reacting with wild-type NPM1.

Download the Latest CST Flyer

Other NPI Flyers

New Products This Month from NEB!

T2104M Monarch® DNase I, Lyophilized – 11,000 U

  • Lyophilized form of DNase I
  • Stable at room temperature for up to 3 years prior to rehydration
  • RNase-free formulation
  • DNase I reaction buffer included
  • Ideal for removal of contaminating genomic DNA from RNA samples
  • Included as a component in Monarch kits, also offered individually for convenience

T5010 6 x 50 ml Magnetic Separation Rack 

  • Streamline high-throughput magnetic bead workflows with simultaneous processing of up to six 50 ml samples
  • Use with standard 50 ml conical tubes – no specialized consumables required
  • Optimally placed strong magnets for quick separation and easy aspiration without disturbing the magnetic bead pellet
  • Recommended for nucleic acid extraction and purification applications, for example, cell-free DNA, cell-free RNA extraction

T4080 Monarch® Mag Cell-free RNA (cfRNA) Extraction Kit 

  • Recover total circulating cfRNA across all fragment sizes, including miRNAs.
  • Isolate circulating cell-free RNA (cfRNA) from biofluids efficiently and phenol-free using a magnetic bead–based workflow 
    – no vacuum manifold required.
  • Simplify workflows with an automation-compatible, high-throughput–ready format.
  • Extract DNA-free cfRNA using included DNase for an on-bead treatment step.
  • Supports scalable sample input volumes.
  • Streamline sample-to-result workflows by integrating with NEB sequencing and amplification solutions.

T3010V Monarch® Spin gDNA Extraction Kit

Effective November 20, 2025, protocols have been updated to remove the low-speed spin step (1000 × g), streamlining the workflow and saving time. Our testing has shown no impact on performance or yield. Kits using orange-tinted Monarch Spin Columns S2C (NEB #T3017) are encouraged to follow the updated protocols for improved efficiency.

  • Extract and purify genomic DNA from a broad range of sample types, such as cells, blood, tissue, bacteria, yeast, saliva, swabs with just this single kit. Suitable for clinically-relevant samples (e.g., saliva, cheek).
  • Isolate high molecular weight gDNA (peak size typically ≥ 50 kb) for use directly in downstream applications, including PCR, qPCR/RT-qPCR, NGS and sequencing.
  • Obtain excellent yields of highly-pure DNA with very low residual RNA contamination (typically <1%) with included RNase A and Proteinase K.
  • Protocol compatible for cleanup of gDNA from other purifications.
  • Kit components and columns also offered separately.
  • For HMW gDNA extraction up to Mb range for long-read sequencing, see related Monarch HMW DNA Extraction Kit for Cells & Blood (NEB #T3050) or Monarch HMW DNA Extraction Kit for Tissue (NEB #T3060).

Learn more about NEB New Products

Extended Right of Use for your commercial cell culture needs

Our channel partner Promocell provides high-quality primary cells and cell culture media to support research and industries. To ensure seamless integration of their products into your commercial processes and in accordance with the rights and permissions granted by us, they offer Extended Right of Use for our primary cells and selected media.

This helps you move forward with confidence, from validation to service delivery.

What is extended right of use?

Enhance experimental consistency with serum-free media

When results vary, it affects more than your data. It costs time and confidence in your research strategy.

In applications where consistency matters most, a more defined environment becomes critical. Serum-free media provide that control. They reduce variability and help keep your workflow stable, so you can move forward with confidence

Download the full flyer

Connect With A Product Specialist

Have you got question? We’d love to hear from you… 

    We’re here for you.

    If you have a question or query relating to specialised equipment or products fill out a contact form. Our Industrial Product Specialists are standing by, waiting to speak with you.