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New Products this month from CST!

LDHA (F3T9U) Rabbit Monoclonal Antibody #71368

IHC-P: IHC analysis of paraffin-embedded mouse colon using #71368

A central enzyme in aerobic glycolysis (Warburg effect)

Lactate dehydrogenase (LDH) catalyzes the interconversion of pyruvate and NADH to lactate and NAD+ in skeletal muscles during intense exercise. The LDHA promoter contains HIF-1α binding sites, and LDHA expression is induced under hypoxic conditions. When oxygen levels return to normal, LDH converts lactate to pyruvate, generating ATP in the mitochondrial electron transport chain. Many cancers rely on aerobic glycolysis (Warburg effect), which converts glucose to lactate even in oxygen-rich environments. LDHA, as a central enzyme in this process, is involved in cancer cell proliferation and prognosis. #71368 is suitable for WB, IHC-P, IF-F, IF-IC, and FC-FP using human, mouse, and rat samples.

CSF-1R/M-CSF-R (F1H1l) Rabbit Monoclonal Antibody #83643

IHC-P: IHC analysis of paraffin-embedded mouse liver using #83643

Macrophage-Associated Transmembrane Tyrosine Kinase

The macrophage colony-stimulating factor (M-CSF, CSF-1) receptor is
a transmembrane tyrosine kinase. Expressed on monocytes, M-CSF receptor promotes the growth and development of this blood cell lineage. M-CSF binding induces receptor dimerization, activation, and autophosphorylation of cytoplasmic tyrosine residues. Phosphorylated Tyr723 binds to the p85 subunit of PI3 kinase and PLCγ2. Overactivation of this receptor has been suggested to cause malignant phenotypes in various cell lines. Activated M-CSF receptor has been shown to be a predictor of poor prognosis in advanced epithelial ovarian and breast cancers. #83643 is suitable for WB and IHC-P using mouse and rat samples.

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New Products This Month from NEB!

Monarch® Mag PCR & DNA Cleanup Kit (5 μg)

  • Magnetic bead-based kit for reliable, high-throughput PCR and DNA cleanup and purification
  • Purify up to 5 μg of DNA using a standard bind-wash-elute workflow
  • Compatible with manual and automated systems to support workflow flexibility
  • No pH monitoring needed, with our optimized buffer chemistry
  • Modified protocols available for purifying oligonucleotides, genomic DNA, and RCA products
  • Additional protocol supports varying DNA binding capacities and sample volumes

RNase Inhibitor, Murine (Glycerol-free)

RNase Inhibitor, Murine, specifically inhibits RNases A, B and C.

  • Glycerol-free version of RNase Inhibitor, Murine (NEB #M0314) supports lyophilization and automation workflows
  • Offers improved resistance to oxidation, compared to human/porcine RNase inhibitor
  • Ideal for reactions where low reducing agent concentrations are required (e.g., RT-qPCR)
  • Isolated from a recombinant source
  • Tested for the absence of nucleases 

Trypsin-ultraâ„¢, Mass Spectrometry Grade (Recombinant)

Trypsin-ultra, Mass Spectrometry Grade (Recombinant) is a serine protease recombinantly expressed in E. coli, originating from porcine trypsin. It is engineered and further chemically modified via methylation to render it highly resistant to autolysis. This enzyme’s high purity and lack of contaminating enzymes, autolysis resistance, and stability make it ideal for a variety of proteomics workflows, including applications that require regulatory compliance.

DNA Gyrase (E. coli)

DNA Gyrase (E. coli) is a Type II topoisomerase that catalyzes the introduction of negative supercoils in DNA in the presence of ATP. The Gyrase holoenzyme is a heterotetramer made up of 2 GyrA (97 kDa) subunits and 2 GyrB (90 kDa) subunits.

E. coli  tRNA

  • Highly active tRNA for in vitro translation
  • Purified by chromatography, no organic solvents
  • Highly pure with undetectable levels of nucleases and proteases
  • Manufactured with reduced environmental impact
  • Compatible with a variety of molecular biology workflows

TET2

  • Demethylase
  • Oxidizes 5-methylcytosine (5mC) through an iterative reaction into 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC),
    and 5-carboxycytosine (5caC)
  • Enables enzymatic strategies for sensitive detection of epigenetic modifications to cytosines

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