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Order your FREE New Student Digital Starter Pack

Start your research journey with support from Cell Signaling Technology. Access a free digital resource pack featuring practical tools and guidance to help you shape your experimental design and approach lab work with confidence. Order yours between September 8 to December 31, 2026. (Terms & Conditions apply.)

You’ll also receive an invitation to our Applications 101 Webinar Series, designed to help you build essential lab skills and lay a strong foundation for a successful research career. The pack includes:

  • Application Guides
  • Invitation to Applications 101: Mastering Research Techniques
  • Tech Tip Videos
  • 25% Off Discount Voucher on Your First Order (expiration March 31, 2027)

Order Here

General Terms and Conditions: Eligibility for the Cell Signaling Technology® New Student Starter Pack requires applicants to be legal residents of Austria, Belgium, Bulgaria, Czechia, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Iceland, Ireland, Israel, Italy, Kazakhstan, Latvia, Lithuania, Luxembourg, Netherlands, Norway, Poland, Portugal, Qatar, Romania, Serbia, Slovakia, Slovenia, South Africa, Spain, Sweden, Switzerland, United Arab Emirates, and United Kingdom  and to provide a business, academic, professional organization email address. Professional email addresses must be new to Cell Signaling Technology (email addresses which have been entered on or before December 1, 2025 will not qualify for the offer). Cell Signaling Technology reserves the right to substitute any item or to stop the promotion at any given time without notice. No product purchase is required to redeem this offer. Offer available until December 31, 2026. All personal information will be handled in accordance with the Cell Signaling Technology privacy policy, www.cellsignal.com/privacy.

Don’t let your antibody become the variable

Recent industry discussions have reinforced the importance of antibody validation and data transparency. Not only does our channel partner Cell Signaling Technology (CST) carry 100 of the most cited antibodies according to CiteAb’s annual reports, their rigorous validation has been the cornerstone of their approach for more than 25 years. 

CST’s unique set of strategies for antibody validation are often used in combination, to give your lab a comprehensive data package that supports antibody performance. 

See the science behind CST validation

New Products This Month

MMP-9 (F1M6L) Rabbit Monoclonal
Antibody #85604

IHC-P: IHC analysis of paraffin-embedded 4T1 syngeneic tumor using #85604.

MMP-9: A Key Regulator of Tissue Regeneration and Destruction

MMP-9 is a secreted endopeptidase that degrades the extracellular matrix
(ECM). Utilizing substrates such as type IV collagen, it is physiologically involved in processes including wound healing, angiogenesis, and synaptic plasticity. Conversely, dysregulation of MMP-9 expression and activity is known to drive various pathological conditions. In oncology, it promotes invasion, metastasis, and tumor angiogenesis, whereas in cardiovascular and cerebrovascular contexts, it is associated with atherosclerotic plaque rupture and blood-brain barrier (BBB) disruption. Furthermore, MMP-9 is deeply implicated in the progression of chronic inflammatory diseases, such as rheumatoid arthritis and inflammatory bowel disease (IBD), as well as neurodegenerative and psychiatric disorders. Consequently, it not only holds the key to elucidating disease mechanisms but is also widely investigated as a potential therapeutic target and biomarker. Antibody #85604 is suitable for WB, IP, and IHC-P applications using mouse and rat samples.

Islet-1 (F4B7I) Rabbit Monoclonal
Antibody #68324

 

IF-F: Confocal IF analysis of dorsal root ganglia in fixed frozen E11.5 mouse embryo labeled with #68324 (red). Free secondary binding sites were then blocked with Rabbit (DA1E) Monoclonal Antibody IgG Isotype Control #3900 prior to co-labeling with Nestin (E5C7I) Rabbit Monoclonal Antibody (Alexa Fluor® 488 Conjugate) #68485 (green) and ProLong Gold Antifade Reagent with DAPI #8961 (blue).

Islet-1: A Key Determinant of Multi-Lineage Cell Fate

Islet-1 (Isl1) is a LIM-homeobox transcription factor that functions as a master regulator driving multi-lineage cell fate determination. Although initially identified as an insulin gene enhancer-binding protein in pancreatic beta-cells, it plays indispensable developmental roles in spinal motor neuron specification as well as the morphogenesis of the pancreas and pituitary gland. Notably, within the cardiovascular system, Islet-1 regulates the maintenance, proliferation, and differentiation of multipotent cardiac progenitor cells in the second heart field (SHF), serving as an essential factor for the structural assembly of the right ventricle and cardiac outflow tract. Mutations or aberrant expression of Islet-1 are linked to the pathogenesis of congenital heart diseases, including Tetralogy of Fallot, as well as diabetes mellitus accompanied by impaired insulin secretion. Furthermore, Islet-1 has garnered significant attention as a histopathological diagnostic biomarker
for neuroendocrine tumors (NETs) and as a primary target for myocardial and pancreatic cell reprogramming in regenerative medicine. #68324 is suitable for WB, IP, IF-F, and IF-IC utilizing human, mouse, and rat samples

Download the Latest CST Flyer

Other NPI Flyers

New Products This Month from NEB!

T2104M Monarch® DNase I, Lyophilized – 11,000 U

  • Lyophilized form of DNase I
  • Stable at room temperature for up to 3 years prior to rehydration
  • RNase-free formulation
  • DNase I reaction buffer included
  • Ideal for removal of contaminating genomic DNA from RNA samples
  • Included as a component in Monarch kits, also offered individually for convenience

T5010 6 x 50 ml Magnetic Separation Rack 

  • Streamline high-throughput magnetic bead workflows with simultaneous processing of up to six 50 ml samples
  • Use with standard 50 ml conical tubes – no specialized consumables required
  • Optimally placed strong magnets for quick separation and easy aspiration without disturbing the magnetic bead pellet
  • Recommended for nucleic acid extraction and purification applications, for example, cell-free DNA, cell-free RNA extraction

T4080 Monarch® Mag Cell-free RNA (cfRNA) Extraction Kit 

  • Recover total circulating cfRNA across all fragment sizes, including miRNAs.
  • Isolate circulating cell-free RNA (cfRNA) from biofluids efficiently and phenol-free using a magnetic bead–based workflow 
    – no vacuum manifold required.
  • Simplify workflows with an automation-compatible, high-throughput–ready format.
  • Extract DNA-free cfRNA using included DNase for an on-bead treatment step.
  • Supports scalable sample input volumes.
  • Streamline sample-to-result workflows by integrating with NEB sequencing and amplification solutions.

T3010V Monarch® Spin gDNA Extraction Kit

Effective November 20, 2025, protocols have been updated to remove the low-speed spin step (1000 × g), streamlining the workflow and saving time. Our testing has shown no impact on performance or yield. Kits using orange-tinted Monarch Spin Columns S2C (NEB #T3017) are encouraged to follow the updated protocols for improved efficiency.

  • Extract and purify genomic DNA from a broad range of sample types, such as cells, blood, tissue, bacteria, yeast, saliva, swabs with just this single kit. Suitable for clinically-relevant samples (e.g., saliva, cheek).
  • Isolate high molecular weight gDNA (peak size typically ≥ 50 kb) for use directly in downstream applications, including PCR, qPCR/RT-qPCR, NGS and sequencing.
  • Obtain excellent yields of highly-pure DNA with very low residual RNA contamination (typically <1%) with included RNase A and Proteinase K.
  • Protocol compatible for cleanup of gDNA from other purifications.
  • Kit components and columns also offered separately.
  • For HMW gDNA extraction up to Mb range for long-read sequencing, see related Monarch HMW DNA Extraction Kit for Cells & Blood (NEB #T3050) or Monarch HMW DNA Extraction Kit for Tissue (NEB #T3060).

Learn more about NEB New Products

Extended Right of Use for your commercial cell culture needs

Our channel partner Promocell provides high-quality primary cells and cell culture media to support research and industries. To ensure seamless integration of their products into your commercial processes and in accordance with the rights and permissions granted by us, they offer Extended Right of Use for our primary cells and selected media.

This helps you move forward with confidence, from validation to service delivery.

What is extended right of use?

Webinar on September 29th

PDOs or Ex Vivo Tumor Tissue Cultures?

Which preclinical model best reflects patient biology? Join this PromoCell webinar as we compare patient-derived organoids (PDOs) and ex vivo tumor slice cultures, exploring where each model excels, where limitations arise, and how to choose the right approach for your translational research goals.   

What you’ll learn: 

  • How PDOs and tumor slice cultures compare across critical factors (tumor microenvironment fidelity, scalability, reproducibility, drug screening and immunotherapy compatibility). 
  • How each model’s strengths and limitations impact translational applications and potential clinical predictivity. 
  • How PromoCell’s innovative 3D Tumorsphere Medium XF, Cancer Cell Line Medium XF, and Primary Cancer Culture System enhance PDO and slice culture workflows.
  • Practical guidance on selecting the most clinically relevant model for your specific translational and drug discovery needs.

When: September 29, 2026. 16:00 IST (11:00 ET)

Where: Online. The session will be recorded if you cannot attend live.

Register Here

Connect With A Product Specialist

Have you got question? We’d love to hear from you… 

    We’re here for you.

    If you have a question or query relating to specialised equipment or products fill out a contact form. Our Industrial Product Specialists are standing by, waiting to speak with you.